内在的功能性皮质组织中的性别差异反映了网络拓学的差异,而不是皮质形态学
Bianca Serio1,2,3,4, Meike D Hettwer1,2,3,4, Lisa Wiersch3,4
1Max Planck School of Cognition, Leipzig, Germany.
bioRxiv : the preprint server for biology
|December 4, 2023
概括
大脑功能的性别差异不仅仅是由大脑的大小或结构来解释的. 功能连接和网络拓在性别之间的内在皮层组织差异中起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 性别差异 性别差异
背景情况:
- 大脑的大小在两性之间有很大的差异,这种现象被称为解剖二态.
- 这种二形态对内在大脑功能的影响仍然不清楚.
- 了解大脑组织中的性别差异对于神经科学研究至关重要.
研究的目的:
- 为了调查内在皮层功能组织中的性别差异是否可以通过皮层形态学上的差异来解释.
- 检查大脑大小,微观结构和地理距离在功能组织中的作用.
- 探索功能连接,网络拓和大脑中的性别差异之间的关系.
主要方法:
- 计算了功能性皮层组织的低维表示,特别是感觉关联轴.
- 评估功能组织中的性别差异.
- 分析了功能组织和形态特征 (大脑大小,微观结构,地理距离) 之间的关联.
主要成果:
- 在功能性皮层组织的感觉关联轴上发现了广泛的性别差异.
- 功能组织中观察到的性别差异与大脑大小,微观结构组织或地理距离的差异没有根本联系.
- 功能性差异与功能连接配置和网络拓学的变化有关.
结论:
- 内在皮层功能组织中的性别差异超越了解剖学和微观结构的差异.
- 功能连接和网络拓是理解大脑功能的基于性别变异的关键因素.
- 这些发现挑战了形态差异完全解释大脑功能性性别差异的假设.
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