血清激素抗抑郁药和心房的负担来自心脏植入式电子设备
Youlin Koh1,2, Cecilia Kwok1, Aleksandr Voskoboinik1,3
1Department of Cardiology Western Health St Albans Victoria Australia.
Journal of arrhythmia
|December 4, 2023
概括
选择性血清素再吸收抑制剂和血清素/上腺素再吸收抑制剂可以减少心房 (AF) 的负担. 这项研究调查了心脏植入装置患者的抗抑郁药使用和AF发作.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 前庭动 (AF) 和精神健康状况,如抑郁和焦虑,共享一个复杂的双向关系.
- 以前的研究表明,抗抑郁药的使用可能会降低AF的发病率.
- 抗抑郁药对AF负担 (在AF中花费的时间) 的影响仍未得到充分研究.
研究的目的:
- 为了研究抗抑郁药的使用和心脏植入装置患者的AF负担之间的关联.
- 分析特定类型抗抑郁药和设备检测到的AF情节之间的关系.
- 探索其他影响AF发病率和负担的治疗因素.
主要方法:
- 从2015年至2021年进行的回顾性队列研究,包括285名从2015年至2021年没有或有发作性AF的患者.
- 使用通用估计方程来建模二进制AF (存在/缺席) 和AF负载 (AF中的天数).
- 分析了772名患者接触的数据,重点关注心脏植入式设备检测到的AF情节.
主要成果:
- 高龄和狄戈辛的使用与发生AF的几率增加有关.
- 索塔醇和心力衰竭β-阻塞剂与减少AF负担有关.
- 选择性血清素再吸收抑制剂 (SSRI) 和血清素/上腺素再吸收抑制剂 (SNRIs) 显著降低了AF负担.
结论:
- 基于血清素的抗抑郁药 (SSRI和SNRIs) 与减少AF负担有关.
- 高龄,女性性别和狄戈辛的使用是发生AF的危险因素.
- 建议进行进一步的前性研究,以证实抗抑郁药对心房失常症的影响.
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