在侵袭性通风COVID-19患者中, ангиотензинII输液和器官功能标志物
Alberto Zangrillo1,2, Sergio Colombo1, Anna Mara Scandroglio1
1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
概括
在通风COVID-19患者的 ангиотензинII疗法改善了血压和氧化,减少了肝功能障碍,并可能降低替代疗法的需要. 需要进一步的研究来证实这些发现.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 在2019年冠状病毒病 (COVID-19) 侵袭性通风患者中使用血管新素II仍然存在争议,对器官功能的影响尚不清楚.
- 机械通风是严重COVID-19的关键干预措施,通常与多器官功能障碍有关.
研究的目的:
- 评估 ангиотензин II 对侵袭性通风COVID-19患者器官功能的影响.
- 在这个患者群体中评估血管素II作为血管压缩剂.
主要方法:
- 在重症监护室 (ICU) 进行的前性观察性研究,涉及机械通风的成年COVID-19患者.
- 46名接受 ангиотензин II 治疗的患者与53名对照患者 (前 ангиотензин II 可用性或邻近的ICU) 的比较.
- 贝叶斯模型应用于数据分析,以评估器官功能影响.
主要成果:
- ангиотензин II 增加了平均动脉压 (9.05 mmHg) 和 PaO2/FiO2 比率 (23.17),并降低了肝功能障碍的几率 (OR,0.32).
- 没有观察到对乳酸,尿液输出,血清肌素,C反应蛋白,血小板计数或血栓栓塞并发症的显著影响.
- 贝叶斯模型表明95.7%的概率降低了替代疗法 (RRT) 用在患者的异常基线血清肌.
结论:
- 透气COVID-19患者的 ангиотензинII疗法改善了血液动力学状态和氧化,减少了肝功能障碍,并显示了预防RRT的潜在益处.
- 观察到的好处被认为是产生假设的,需要进一步调查.
- 临床试验.gov标识符:NCT04318366.gov标识符:NCT04318366.gov标识符:NCT04318366.gov标识符:NCT04318366.gov标识符:NCT04318366.
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