在癌症向治疗患者中,甲状腺功能障碍的患病率和相关因素:来自泰国的单中心研究
Korawan Chawalitmongkol1, Kunlatida Maneenil2, Pravinwan Thungthong3
1Division of Endocrinology and Metabolism, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
Journal of the ASEAN Federation of Endocrine Societies
|December 4, 2023
概括
甲状腺功能障碍在癌症患者中很常见,这些癌症患者服用铁激酶抑制剂 (TKI) 和免疫检查点抑制剂 (ICI). 甲状腺瘤感染会导致轻度问题,而ICI通常会导致明显的甲状腺功能低下症,需要使用levothyroxine.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗癌疗法,如氨酸激酶抑制剂 (TKI) 和免疫检查点抑制剂 (ICI),可以影响甲状腺功能.
- 对接受这些治疗的患者来说,监测甲状腺功能至关重要.
研究的目的:
- 调查使用TKI和ICI治疗的癌症患者甲状腺功能障碍的患病率和危险因素.
- 为了比较TKI与ICI诱导的甲状腺功能障碍的特征.
主要方法:
- 对TKI治疗患者的横截面研究和对ICI治疗患者的回顾性图表审查.
- 进行了甲状腺功能测试 (TFT),如果发现异常,则测试甲状腺自身抗体.
主要成果:
- 甲状腺功能障碍发生在14.6%的TKI患者中,主要是亚临床甲状腺功能障碍,与男性性别,CKD和HBV相关.
- 甲状腺功能障碍影响了50%的ICI患者,在6个月内经常出现明显的甲状腺功能低下症,需要进行levothyroxine替代治疗.
结论:
- 甲状腺干扰与大多数轻度,无症状的甲状腺功能障碍有关.
- ICI经常诱导明显的甲状腺功能低下症,需要立即进行甲状腺激素替代疗法.
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