主体-病原体的共同进化促进了一般性,广泛的耐药性的进化,并减少了外来病原体溢出风险
Samuel V Hulse1, Janis Antonovics2, Michael E Hood3
1Department of Biology, University of Maryland at College Park, College Park, MD, United States.
Evolution letters
|December 4, 2023
概括
与特有病原体的对抗性共同进化扩大了宿主群体的一般耐药性. 这增加了遗传多样性,并减少了对外来病原体溢出影响的脆弱性,特别是当耐药性基因没有联系时.
科学领域:
- 进化生物学是进化的生物学.
- 植物病理学 植物病理学
- 人口遗传学 人口遗传学
背景情况:
- 宿主耐药性的遗传变异会影响病原体的传播.
- 一般耐药性会影响外来病原体的传播,而特异性耐药性则会准特有病原体.
- 主体和特有病原体之间的对抗性共同进化是一个关键的进化驱动因素.
研究的目的:
- 为了研究在特定的阻力位点的共同进化如何影响一般的阻力频率.
- 确定共进化的对宿主对外来病原体脆弱性的影响.
- 探索维护遗传多样性和耐药性的相关性.
主要方法:
- 开发了一种具有可变重组的双位点种群遗传模型.
- 集成的一般性耐药性 (对所有病原体有效) 和特异性耐药性 (仅对特有病原体有效).
- 分析了同进化动态和基因链接对抗性进化的影响.
主要成果:
- 同进化显著扩大了一般耐药性进化的条件,减少了外来病原体入侵风险.
- 同进化促进了在抵抗位点的多态维护,增加了宿主遗传多样性.
- 对外来和特有病原体的耐药性之间的正相关性是常见的,但链接可以诱导负相关性.
结论:
- 与特有病原体的共同进化动态塑造宿主耐药性结构,影响对外国溢出效应的易感性.
- 抗性成本和基因链接之间的相互作用决定了进化结果.
- 由共同进化驱动的基因多样性的增加可以增强宿主群体的弹性.
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