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Hwei-Yen Chen^1,2, Therese Krieg¹, Brian Mautz³

¹Department of Ecology and Genetics, Uppsala University, Uppsala, Sweden.

Evolution letters

|December 4, 2023

概括

父母的年龄会影响生殖线突变率. 在Caenorhabditis remanei的最高生殖年龄显示突变率降低,这表明在此期间DNA修复得到改善.

科学领域:

进化遗传学的进化遗传学
分子生物学分子生物学
发育生物学是发展生物学.

背景情况:

父母年龄和生殖线突变率之间的关系是复杂的,并进行了辩论.
之前的研究表明,关于突变率的线性性和年龄依赖性,结果相互矛盾.

研究的目的:

调查父母年龄对Caenorhabditis remanei的生殖线突变积累的影响.
为了比较不同父母年龄组 (年轻,高峰,老年) 的突变率.

主要方法:

在C. remanei中,来自不同年龄的父母 (第1天,第2天,第5天) 的复制突变积累线的产生.
全基因组重新排序和变异调用,以量化三代后的突变率.
基于变异影响的突变模式的分析 (例如,高影响,修饰剂,基因间).

主要成果:

与年轻的 (1日) 和老的 (5日) 父母相比,来自生殖年龄高峰的父母 (2日) 的突变积累线呈现出总体减少的突变率.
在高峰年龄父母的血统中没有检测到任何高影响变异.
修饰剂和基因间变异的频率在来自高峰年龄父母的血统中较低.

结论:

与年轻或年长个体相比,在繁殖年龄高峰的动物具有增强的DNA维护和修复机制.
C. remanei可能会优先考虑早期的繁殖而不是最佳的DNA修复,从而随着年龄的增长而增加后代的突变负载.
随着父母年龄的增长,观察到的突变负载的增加很可能反映出生殖线衰老.

关键词:

国家统一计划 (SNP) 是一个国家统一计划.与年龄相关的突变率与年龄相关的突变率生殖线突变的发生.突变的积累是突变的积累.父母的年龄影响选择阴影的选择

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