怀孕期间的炎症状况和自闭症和其他神经发育障碍的风险
Lisa A Croen1,2, Jennifer L Ames1, Yinge Qian1
1Division of Research, Kaiser Permanente Northern California, Oakland, California.
Biological psychiatry global open science
|December 4, 2023
概括
孕产妇的喘和怀孕期间的肥胖与儿童,特别是女孩的自闭症谱系障碍 (ASD) 风险增加有关. 这些关联似乎源于共同的环境因素,而不是遗传.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 怀孕期间由免疫或代谢问题引起的孕产妇炎症可能会影响神经发育结果.
- 孕产妇的炎症状况与自闭症谱系障碍 (ASD) 或其他发育障碍 (DD) 的风险之间的关系需要进一步研究.
研究的目的:
- 调查怀孕期间母亲免疫介导和心脏代谢条件与后代ASD和DDs风险之间的联系.
- 使用遗传数据探索潜在的因果关系.
主要方法:
- 一项病例控制研究使用了2011年至2016年间在加利福尼亚州出生的儿童的数据.
- 从电子健康记录中提取了母亲的病情,并使用多变量逻辑回归来分析关联.
- 母亲遗传数据被用于多基因风险评分分析和门德尔随机化.
主要成果:
- 母亲喘与ASD (OR=1.62) 和DDs (OR=1.30) 的几率增加有关.
- 孕产妇的肥胖与ASD的更高几率有关 (OR=1.51).
- 孕产妇喘和极度肥胖的组合显示,ASD的风险显著增加 (OR=16.9),特别是在女婴中. 遗传分析没有支持因果关系.
结论:
- 怀孕期间的炎症和心脏代谢状况与儿童神经发育障碍的风险增加有关.
- 观察到的关联很可能是由于共同的非遗传风险因素而不是遗传倾向.
- 早期查和干预可能有利于怀孕期间患有喘和肥胖的母亲所生孩子.
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