双胞胎细菌物种对糖的优先利用
Ryuta Murakami1, Keisuke Yoshida1, Mikiyasu Sakanaka2
1Next Generation Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan.
Microbiome research reports
|December 4, 2023
概括
双菌物种对利用葡萄糖或乳糖表现出明显的偏好,受其宿主的影响.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 营养科学 营养科学
背景情况:
- 双菌对宿主健康至关重要,从碳水化合物中产生有益的有机酸.
- 了解双细菌的糖偏好对于利用它们的益生菌潜力至关重要.
- 关于Bifidobacterium物种中特定的碳水化合物利用模式的知识有限.
研究的目的:
- 为了研究不同Bifidobacterium物种的糖利用偏好 (葡萄糖与乳糖).
- 为了将糖偏好与基因组信息和宿主环境相关联.
- 提供Bifidobacterium糖吸收的系统评估.
主要方法:
- 在葡萄糖和/或乳糖上培养40种Bifidobacterium物种/亚种.
- 使用高性能薄层染色学 (HPTLC) 评估优先糖利用率.
- 进行碳水化合物代谢基因的比较基因组分析.
主要成果:
- 鉴定了Bifidobacterium菌株,首选使用葡萄糖或乳糖.
- 偏爱乳糖的菌株主要具有乳糖共载体 (lacS) 基因.
- 与糖偏好相关的隔离源:人类隔离物偏好乳糖,昆虫隔离物偏好葡萄糖.
- 宿主牛奶中的乳糖含量和婴儿便中的乳糖也表明了宿主饮食的影响.
结论:
- 双杆菌的糖偏好受到宿主的饮食习惯和环境的显著影响.
- 这项研究提供了首次对不同Bifidobacterium物种的糖摄入偏好进行系统分析.
- 这些发现表明Bifidobacterium碳水化合物代谢中的宿主特异性适应.
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