对认知功能有负面影响的药物 (第一部分):慢性病作为危险因素
Sophie Liabeuf1,2, Vesna Pešić3, Goce Spasovski4
1Pharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens University Medical Center, Amiens, France.
Clinical kidney journal
|December 4, 2023
概括
慢性病 (CKD) 患者经常因药物的副作用而经历认知障碍. 本综述探讨了CKD和透析如何影响药物处理,增加中枢神经系统 (CNS) 的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经科学是一个神经科学.
- 临床药理学 临床药理学
背景情况:
- 慢性病 (CKD) 与认知障碍和神经认知障碍有关.
- 慢性病患者经常有多种并发症,导致多种药物治疗和增加药物不良反应的风险.
- 尿液中毒素和CKD中改变的药理动力学可以破坏血脑屏障 (BBB) 并影响中枢神经系统 (CNS).
研究的目的:
- 审查导致CKD患者认知障碍的药物不良反应作为可修改的风险因素.
- 检查CKD在增加中枢神经系统药物不良反应风险方面的作用.
- 讨论功能下降和透析对慢性病患者药物药理动学的影响.
主要方法:
- 文献综述侧重于慢性脏病中药物不良反应和认知障碍.
- 由于功能受损和透析而导致的药物动力学变化的分析.
- 在CKD的背景下检查血脑屏障 (BBB) 完整性.
主要成果:
- 慢性瘤是中枢神经系统不良药物反应的重要危险因素,有助于认知障碍.
- 在CKD患者中,多种药物加剧了与药物相关的副作用的风险.
- 减少药物分泌和改变CKD和透析中的药理动力学需要仔细调整剂量.
结论:
- 药物不良反应是CKD认知障碍的潜在可改变的原因.
- 了解CKD的药理动力学变化对于管理药物安全性和预防中枢神经系统毒性至关重要.
- 本综述强调了在药物管理中考虑CKD特异性因素的重要性,以减轻认知风险.
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