血活性蛋白A随着功能下降而上升,并且与慢性病患者的死亡率独立相关
Anders Nordholm1,2, Ida M H Sørensen1, Sasha S Bjergfelt1,3
1Department of Nephrology, Rigshospitalet, Copenhagen, Denmark.
Clinical kidney journal
|December 4, 2023
概括
血激素A在慢性病 (CKD) 中升高,并与较高的死亡风险有关. 这项研究发现,随着功能下降,激素A水平增加,并且独立预测CKD患者的死亡.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
背景情况:
- 血激素A在慢性病-矿物质和骨疾病 (CKD-MBD) 中升高.
- 在动物模型中,激素A抑制可改善CKD-MBD并发症.
- 血激素A在CKD患者结局中的作用需要研究.
研究的目的:
- 检查血激素A与主要心血管不良事件 (MACE),全因死亡率和CKD-MBD并发症在CKD患者中的关联.
主要方法:
- 916名参与者 (741名CKD患者,175名对照) 的前性队列研究.
- 评估的血活性蛋白A水平与估计的膜过率 (eGFR),血管化 (Agatston分数) 和骨矿物质密度 (BMD) 相比.
- 通过生存分析 (Aalen-Johansen/Kaplan-Meier) 和Cox回归,评估与MACE的相关性和全因死亡率.
主要成果:
- 血激素A随着CKD阶段的增加而增加,与eGFR相反相关 (r = -0.53,P < .01).
- 血激素A与所有原因死亡率相关 (HR1.55,P<.05) 独立于年龄,性别,糖尿病 (DM) 和eGFR.
- 在eGFR调整后,在血激素A和MACE,血管化或BMD之间没有发现显著的关联.
结论:
- 血活性蛋白A水平随着功能下降而上升.
- 血激素A的升高是CKD患者全因死亡率的独立预测因子.
- 在这个队列中,血激素A与MACE,血管化或BMD没有显著的关联.
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