治疗作为维护血液透析中预防HCV消除的预防:一个多中心的前性队列研究
Chung-Feng Huang1,2,3, Chia-Yen Dai1,3, Chih-Wen Wang1,4
1Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Clinical kidney journal
|December 4, 2023
概括
作为预防的治疗有效地消除了血液透析患者的C型肝炎病毒 (HCV). 这一策略显著降低了HCV病毒性血清,并预防了新的感染,证明了成功的微清除计划.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 世界卫生组织 (WHO) 为消除C型肝炎病毒 (HCV) 提供了临时指导.
- 血液透析 (HD) 患者是HCV传播和再感染的脆弱人群.
- 这项研究研究了"作为预防的治疗",作为一种HD环境中消除HCV的策略.
研究的目的:
- 为血液透析患者实施和评估潜在的HCV消除计划.
- 为了证明"作为预防的治疗"在减少HCV病毒病和发病率方面的有效性.
- 评估将病毒性患者与直接作用抗病毒疗法 (DAA) 联系的影响.
主要方法:
- 2019年,在22个HD中心进行了普遍的HCV查.
- 患有HCV病毒的患者接受了直接作用抗病毒药物 (DAA) 的治疗.
- 2021年进行的第二次查评估了HCV病毒病发病率和新/再感染的变化.
主要成果:
- 在2019年,2336名HD患者中有7.7%是HCV病毒性;92.1%的治疗患者实现了持续的病毒学反应.
- 到2021年,整体HCV病毒发病率降至0.6% (15/2353).
- 在45.5%的中心,HCV被根除了,82%的单位报告没有新的感染或再感染.
结论:
- "治疗作为预防"的方法,通过HCV微分泌,成功地预防了HD群体的再感染和新感染.
- 这一策略在高风险的HD患者队列中有效地消除了HCV.
- 临床试验.gov的标识符:NCT03803410和NCT03891550.gov的标识符:NCT03803410和NCT03891550.gov的标识符:NCT03803410和NCT03891550.gov的标识符:NCT03803410和NCT03891550.gov的标识符:NCT03803410和NCT03891550.gov的标识符:NCT03891550.gov的标识符:NCT03803410和NCT03891550.
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