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银纳米颗粒对不同生物模型的发育影响和毒理学标志
Yán Wāng1, Yapeng Han1, De-Xiang Xu1
1Department of Toxicology, School of Public Health & Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China.
Environmental science and ecotechnology
|December 4, 2023
概括
银纳米颗粒 (AgNPs) 显示出抗菌作用的好处,但存在发育毒性风险. 研究强调对胎儿发育和成年后代健康的影响,需要进一步调查.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 发展生物学 发展生物学
背景情况:
- 银纳米粒子 (AgNPs) 由于其在各种产品中的抗菌特性而被广泛使用.
- 人们担心AgNP对胎儿发育和长期健康的潜在不良影响.
- 了解AgNP发育性毒性至关重要,因为它们的流行率越来越高.
研究的目的:
- 在各种动物和体外模型中审查AgNP的发育毒性.
- 阐明在发育过程中与AgNP暴露相关的危险结果.
- 确定AgNP发育毒性的潜在机制和长期后果.
主要方法:
- 对水生物种 (斑马鱼,鱼) 和哺乳动物 (动物) 的AgNP发育毒性研究的文献综述.
- 检查使用胚胎干细胞的体外研究.
- 对AgNP命运,危险结果和对后代的持久影响的分析.
主要成果:
- 在各种模型中,AgNP会导致胚胎毒性和不良妊娠结果.
- 后代表现出神经行为障碍,生殖问题,心肺病变和肝毒性.
- 关键的毒性机制包括氧化还原失衡,炎症,DNA损伤和线粒体应激.
结论:
- 在发育过程中暴露于AgNP可以导致后代的显著,持久的不良健康影响.
- 免疫调节功能障碍和表观遗传变化是AgNP诱导的发育损害的潜在贡献者.
- 进一步的研究是必不可少的,以充分理解和减轻与AgNP相关的发育风险.
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