在患有家族地中海热病的患者中评估周围神经干扰
Atak Karabacak1, Rahşan İnan1, Nesrin Şen2
1Department of Neurology, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Türkiye.
Archives of rheumatology
|December 4, 2023
概括
家庭地中海热 (FMF) 患者表现出较高的手管综合征率和潜在的亚临床自主功能障碍. 神经传导研究显示多神经病变和手掌道综合征,同情性皮肤反应幅度降低.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 自主神经科学 自主神经科学
背景情况:
- 家庭地中海热 (FMF) 是一种遗传性自身炎症性疾病.
- 外周和自主神经参与是FMF的潜在并发症.
研究的目的:
- 评估FMF患者的外周和自主神经功能.
- 在FMF患者中评估神经传导,同情性皮肤反应 (SSR) 和RR间隔变化 (RRIV).
主要方法:
- 一个比较病例系列包括46名FMF患者和30名健康对照.
- 进行了神经传导研究,SSR和RRIV.
- 评估了自主症状和神经病障碍残疾分数.
主要成果:
- 在FMF患者中检测到多神经病 (15.21%) 和手腕道综合征 (13.04%).
- 与对照组相比,在FMF患者中观察到明显较低的SSR幅度 (p=0.041).
- RRIV显示了FMF患者减少的趋势,但没有统计学意义.
结论:
- 患有FMF的患者患手腕道综合征的患病率高于一般人群.
- 结果表明,在FMF患者中存在亚临床的dysautonomia.
- 需要进一步的研究来阐明神经参与FMF的机制.
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