炎症性关节炎患者中B型和C型肝炎的流行病学特征:来自宝藏数据库的含义
Emine Duygu Ersözlü1, Mustafa Ekici2, Belkis Nihan Coşkun3
1Department of Internal Medicine, Division of Rheumatology, Adana City Training and Research Hospital, Adana, Türkiye.
Archives of rheumatology
|December 4, 2023
概括
这项研究发现,在接受生物治疗的风湿性关节炎或脊椎关节炎患者中,乙型肝炎和型肝炎的发病率较低. 乙型肝炎的重新激活是罕见的,突出显示了这些患者查和预防的重要性.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 患有类风湿性关节炎 (RA) 和脊椎关节炎 (SpA) 的患者经常接受免疫抑制生物治疗.
- 在开始这些疗法之前,查病毒性肝炎,包括乙型肝炎 (HBV) 和C型肝炎 (HCV),至关重要,以防止重新激活和管理患者的护理.
- 了解这些患者群体中病毒性肝炎的患病率和特征对于有效的临床管理至关重要.
研究的目的:
- 在接受生物治疗的RA和SpA患者中确定HBV和HCV感染的频率和临床特征.
- 分析患者的人口统计,并发症和治疗模式,与病毒性肝炎状态相关.
- 提供来自风湿病学实践中大型,有前景的注册表的最新流行病学数据.
主要方法:
- 一项使用前性TReasure数据库数据的观察性研究 (2017年12月-2021年6月).
- 分析包括来自土耳其17个中心的3,147名RA患者和6,071名SpA患者.
- 收集的数据涵盖病毒性肝炎查,患者特征和使用的生物修饰性抗风湿药物 (bDMARDs).
主要成果:
- 肝炎病毒查率很高 (97%在RA,94.2%在SPA).
- 乙肝表面抗原 (HBsAg) 的阳性在RA中为2.6%,在SpA中为2%. 对HCV阳性的抗体在RA中为0.8%,在SpA中为0.3%.
- 具有HBsAg阳性的患者年龄较大,患有更多的并发病 (高血压,糖尿病,冠状动脉疾病) 和较高的类风湿因子阳性. 在接受Rituximab与tenofovir预防治疗的RA患者中,发生了一例HBV重新激活.
结论:
- 该研究提供了来自TReasure注册表的生物制剂的RA和SpA患者病毒性肝炎的最新流行病学数据.
- 观察到活跃的HBV和HCV感染的患病率较低,但HBsAg阳性患者有显著的并发症.
- 有效的患者管理需要了解这些流行病学特征,并实施适当的查和预防措施.
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