将CPRD AURUM数据转换为OMOP通用数据模型
1Lister Hill National Center for Biomedical Communication, National Library of Medicine, NIH Bethesda, MD, USA.
Informatics in medicine unlocked
|December 4, 2023
概括
临床实践研究数据链接 (CPRD) AURUM数据已成功转换为观察医学结果伙伴关系 (OMOP) 共同数据模型 (CDM). 这种标准化增强了数据的可重复使用性,用于使用现有工具进行未来的研究.
科学领域:
- 医疗信息学 医疗信息学
- 数据标准化数据标准化
- 临床数据管理 临床数据管理
背景情况:
- 使用共同数据模型 (CDM) 标准化临床数据,有助于数据的理解和工具的重用.
- 观察医学结果伙伴关系 (OMOP) 共同数据模型 (CDM) 是一个广泛采用的标准.
- 临床实践研究数据链 (CPRD) 在英国收集有价值的全科医生数据.
研究的目的:
- 为了将CPRD AURUM数据的静态数据集转换为OMOP CDM.
- 在转换的OMOP CDM数据上评估现有工具的有效性.
主要方法:
- 使用CPRD文件的直接映射与可比的OMOPCDM表 (例如,患者与人,药物问题与药物暴露).
- 利用CPRD观测文件的间接映射,将数据分配到基于域的适当的OMOP表/列.
- 将所有源值转换为标准化的OMOP概念.
主要成果:
- OMOP CDM 转换结果为 12 个表和超过 200 亿行,其中测量表是最大的.
- 发现60.2%的源概念是标准的OMOP概念,药物暴露表具有最低的百分比 (4.7%).
- 数据损失最小,仅有2.00%的行被排除在外,因为缺乏明确的匹配.
结论:
- CPRD AURUM数据已成功转化为OMOP CDM,数据损失最小.
- 现有的观察健康数据科学和信息学 (OHDSI) 工具证明了转换数据的实用性.
- 标准化的CPRD AURUM数据显著提高了其未来研究应用的潜力.
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