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相关概念视频

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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相关实验视频

Updated: Jul 9, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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挖掘剂量响应途径的毒基因组数据:在推进下一代风险评估方面的影响

A Rasim Barutcu1, Michael B Black1, Andy Nong1

  • 1ScitoVation LLC, Durham, NC, United States.

Frontiers in toxicology
|December 4, 2023
PubMed
概括

公正的转录组分析揭示了剂量反应性毒性途径和出发点,改善了化学风险评估. 这种系统毒理学方法补充了针对全面评估的有针对性的方法.

科学领域:

  • 毒理学 毒理学 毒理学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 有针对性的毒性路径调查有助于发现生物标志物.
  • 无偏见的系统级转录组分析提供了一个互补的视角.
  • 系统地实施无偏向的转录组方法仍然不发达.

研究的目的:

  • 展示综合生物信息学方法分析转录基因组数据的力量.
  • 以非有针对性的方式识别剂量响应的分子变化,生物途径和起点.
  • 评估系统毒理学对改进化学风险评估的有用性.

主要方法:

  • 对44种ToxCast化学品的公开可用的MCF7细胞TempO-seq数据进行重新分析.
  • 综合生物信息工作流:差异表达,基因组丰富,基准剂量建模,网络可视化.
  • 与原始研究的基因签名方法和ToxCast高通量查 (HTS) 试验的比较.

主要成果:

  • 确定了对剂量反应的分子变化和扰乱的生物途径.
  • 基准剂量建模基于路径总结的顶点终点的起点.
  • 揭示了单个终点分析遗漏的额外扰乱机制.
关键词:
在 BMD 建模中使用 BMD 模型.这个名字是NAM NAM.剂量响应剂量响应.有毒基因组学 (Tgx)翻译学 翻译学 翻译学 翻译学

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Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
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Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

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Last Updated: Jul 9, 2025

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Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

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结论:

  • 系统毒理学为化学暴露的影响提供了多方面的见解.
  • 公正的,数据驱动的技术与针对性的方法一起对于全面的毒性评估至关重要.
  • 将omics测定与生物信息学相结合,可以提高化学风险评估,并支持新方法方法 (NAM).