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在大鼠中,将压力与尿皮质激素联系起来
Manikandan Balraj1, Ankamma Sarvepalli2, Bijoya Chatterjee3
1Department of Physiology, Konaseema Institute Medical Science and Research Foundation, Amalapuram, East Gothawri - 533201, Andhra Pradesh, India.
Bioinformation
|December 4, 2023
概括
慢性变量压力会改变大脑的尿皮质激素 (UCN) 水平,并提高大鼠的皮质. 这表明压力刺激了下丘脑-垂体-上腺轴和边缘系统,影响了UCN基因表达.
科学领域:
- 神经内分泌学神经内分泌学
- 压力生理学 压力生理学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 皮质otropin释放因子 (CRF) 神经和spexin调节能量平衡和食物摄入.
- 慢性变量压力对这些神经的影响尚不清楚.
研究的目的:
- 研究慢性可变压力对大鼠循环皮质和大脑尿皮质素 (UCN) 表达的影响.
- 阐明压力,UCN水平和下丘脑-垂体-上腺 (HPA) 轴之间的关系.
主要方法:
- 对实验大鼠实施了为期28天的慢性变量压力方案.
- 使用RT-PCR分析了大脑UCN-1,2,3表达.
- 血清皮质水平通过ELISA测量.
主要成果:
- 长时间的可变压力显著改变了大脑UCN水平在老鼠.
- 升高的皮质水平与UCN表达模式相关.
- 数据表明,葡萄糖皮质体通过一种葡萄糖皮质体反应元件 (GRE) 调节UCN表达.
结论:
- 压力刺激下丘脑-垂体-上腺 (HPA) 轴和边缘系统,导致皮质类固醇的增加.
- UCN基因 (UCN1,2和3) 与应激反应有关.
- 在慢性压力期间,葡萄糖皮质类药物调节了乌洛科丁的表达.
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