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多胎妊娠作为SARS-CoV-2-相关不良孕产妇结果的危险因素:来自COVID-19相关产科和新生儿结果研究 (CRONOS) 的数据
Marina Sourouni1,2, Ariane Germeyer1, Manuel Feißt3
1Gynäkologische Endokrinologie und Fertilitätsstörungen, University Hospital Heidelberg, Heidelberg, Germany.
Geburtshilfe und Frauenheilkunde
|December 4, 2023
概括
多胎妊娠增加了孕妇严重COVID-19结果的风险,不良事件比单胎妊娠更早发生. 这凸显了监测高风险怀孕的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 患有COVID-19的孕妇面临更高的ICU入院和机械通风的风险.
- 怀孕期间的生理呼吸道变化,特别是多胎妊娠,可能会加剧COVID-19的严重程度.
- 多重怀孕可能会早些时候损害肺功能,可能导致严重的呼吸道症状.
研究的目的:
- 为了比较COVID-19相关的多胎和单胎怀孕之间的不良孕产妇结果.
- 为了确定与孕妇严重COVID-19结局相关的风险因素.
主要方法:
- 对5514名患有SARS-CoV-2感染症状的孕妇进行分析.
- 在165个多胎与5349个单胎怀孕中对母亲不良结果的比较.
- 多变量逻辑回归用于确定不利结果的几率比率.
主要成果:
- 多重怀孕,怀孕前的BMI>30 kg/m2,和怀孕年龄显著与联合不良母亲结果的风险增加相关.
- 与单胎妊娠相比,多胎妊娠的不良结果发生在怀孕的早期.
- 两组之间单一或联合不良结果的总体发病率没有显著差异,但严重程度和时间不同.
结论:
- 多胎妊娠是COVID-19相关的母亲不良后果的独立风险因素.
- 严重的COVID-19课程在多次怀孕中,在怀孕中表现得比单个怀孕更早.
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