电气喷雾净化曼吉费林纳米颗粒的潜力用于抗衰老化品应用
Neungreuthai Chomchoei1,2, Pimporn Leelapornpisid2,3, Pratchaya Tipduangta2
1PhD Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University Chiang Mai 50200 Thailand.
RSC advances
|December 4, 2023
概括
使用纤维素酸盐进行电喷制造的曼吉费林纳米粒子 (MNPs),增强纯度和生物活性. 这些MNP显示出由于改善皮肤透性和安全性而具有化品应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 化品科学 化品科学
背景情况:
- 曼吉费林是一种天然化合物,具有抗氧化和抗衰老的特性.
- 改善曼吉费林的纯度和输送对于提高生物效率至关重要.
- 电子喷涂为纳米粒子制造提供了一种新的方法.
研究的目的:
- 使用纤维素酸盐通过电喷制造曼吉费林纳米粒子 (MNPs).
- 为了描述纯化的曼吉费林和制造的MNP.
- 评估MNP在化品应用中的皮肤透,释放和安全性.
主要方法:
- 通过再结晶来净化曼吉费林.
- 使用DSC,FTIR,XRD,HPLC和SEM进行表征.
- 电子喷雾制造具有各种参数的MNP.
- 在体外皮肤透,释放和HET-CAM刺激测试.
主要成果:
- 再结晶的曼吉费林显示了纯度的提高 (95.71%) 和增强的生物活性.
- MNPs表现出球形形态,尺寸在295-448nm之间.
- 高封装效率 (85.31%) 和显著的皮肤透到角层和皮肤.
- MNPs表现出抗氧化,抗衰老的特性,以及轻微的刺激.
结论:
- 电子喷雾是一种有效的生产曼吉费林纳米颗粒的方法.
- 许多MNP显示出作为安全和高效的化品应用交付系统的巨大潜力.
- 增强的mangiferin纯度和纳米颗粒配方改善了皮肤透和生物活性.
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