根据NHANES汇集的生物监测数据,评估美国人暴露于PCB和PBDE的差异
Yan Liu1, Dewei Wang2, Li Li1
1School of Public Health, University of Nevada, Reno, NV 89557, USA.
Journal of the American Statistical Association
|December 4, 2023
概括
现在,NHANES对多二 (PCB) 和多二乙烯 (PBDE) 的生物监测使用了聚合数据. 一种新的方法解开了这些测量,揭示了化学物质暴露的年龄,收入和种族差异.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物监测 生物监测
背景情况:
- 国家健康和营养检查调查 (NHANES) 监测美国对PCB和PBDE等有害化学物质的暴露.
- 节约成本的措施导致NHANES在2005年采用了聚合生物监测,限制了数据在健康研究中的应用.
- 现有的聚合数据分析缺乏对混效应的控制,阻碍了全面的差异评估.
研究的目的:
- 开发一种用于分析NHANES聚合生物监测数据的统计方法.
- 综合评估暴露在PCB和PBDE中的差异.
- 评估有关化学物质暴露水平的监管政策的有效性.
主要方法:
- 开发了一种基于回归的方法来"unzip"聚合生物监测测量.
- 分析了NHANES数据,以评估PCB和PBDE暴露的人口和社会经济差异.
- 在分析种族/民族差异时,对潜在的混因素进行控制.
主要成果:
- PCB 含量显示出与年龄和收入的依赖性越来越大.
- 青少年和老年人的PBDE水平最高,低收入人群的PBDE水平较高.
- 在控制混杂因子后,西班牙裔人表现出最低的PCB和PBDE水平.
- 在研究期间,PCB和PBDE水平均下降.
结论:
- 开发的方法使得聚合生物监测数据的详细分析成为可能,揭示了显著的暴露差异.
- 调查结果强调需要针对特定人口的干预措施,以解决与化学物质接触有关的环境不公正问题.
- 化学物质水平的下降表明当前环境监管政策的成功.
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