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在一个人性化的免疫系统小鼠模型中利用人类TLR选择性连接体来研究人类TLR4信号传递

Rachel Twomey1, Sean Graham1, Joseph S Spina1

  • 1AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605.

Journal of biological methods
|December 4, 2023
PubMed
概括

人性化的小鼠模型显示出对药物测试的希望. 人类TLR4激动剂AZ617在这些模型中选择性地触发了人类细胞因子的释放,验证了它们用于研究托尔类受体 (TLR) 信号抑制剂的用途.

关键词:
在AZ61717中,它是AZ617的.伊拉克4 伊拉克4huNOG-EXL 在线观看人类细胞因子诱导人类造血干细胞是人类的造血干细胞.人性化的小鼠.类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型:这是一种类似收费的受体.

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