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血细胞白血病-临床病理学概况来自印度西部的第三级护理中心

Poornima Manimaran¹, Varnika Rai¹, Rahul Ranka¹

¹Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India.

South Asian journal of cancer

|December 4, 2023

概括

血细胞白血病 (PCL) 是一种罕见的,激进的血液癌症. 这项研究发现,目前的治疗方法没有提供生存优势,突显了需要新的治疗方法,以获得更好的结果在PCL患者.

科学领域:

血液学血液学血液学
在瘤学瘤学.
临床研究临床研究

背景情况:

血细胞白血病 (PCL) 是一种不常见且具有攻击性的血细胞瘤,占血细胞失色病例的2-4%.
PCL是由外周血液中≥20%的克隆性血细胞或2×109细胞/mm3.3的绝对计数定义的.
这种疾病可以表现为多发性骨髓瘤的初级或二级.

研究的目的:

分析PCL患者的临床血液学特征.
为了将免疫表型特征和常规疗法与整体存活率相关联.
评估PCL中特定免疫类型标志物的预后意义.

主要方法:

在印度西部的三级护理中心,对39名在2010-2021年期间被诊断为PCL患者进行了回顾性研究.
收集的数据包括临床,生化,外围涂抹,骨髓吸附物,免疫类型和分子分析.
对接受VTD (博特佐米布,沙利多米德,德克萨米松) 和VCD (博特佐米布,环胺,德克萨米松) 疗法治疗的患者进行了生存分析.

主要成果:

这项研究包括39名PCL患者 (36名初级患者). 常见的发现包括贫血,血小板缺血和性骨损伤 (69.2%).
免疫类型定型显示CD38 (100%),CD138 (62%),CD56 (41.6%) 和CD117 (89%负) 的阳性.
总生存时间为4.1个月;在VTD和VCD疗法之间没有显著差异 (p=0.816). CD117和CD56缺乏预后价值.

结论:

由于PCL的罕见性,有限的前性研究使管理和结果分析复杂化.
目前的治疗方案 (VTD,VCD) 在PCL中没有提供生存优势.
新的治疗策略对于改善血细胞白血病患者的治疗结果至关重要.

关键词:

在 CD117 中,CD117 是 CD117 的第一个版本.CD56 CD56 是一个CD56 CD56 是一个CD56 CD56 循环的血细胞循环的血细胞.没有成熟的血细胞.血细胞白血病血细胞白血病

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