富含非常长链多不和脂肪酸的食鱼油可以降低心脏代谢风险因素,改善视网膜功能
Zhi-Hong Yang1, Aruna Gorusupudi2, Todd A Lydic3
1Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
iScience
|December 4, 2023
概括
鱼油产生非常长链多不和脂肪酸 (VLCPUFA),改善心脏代谢和眼睛健康. 这项研究证明了VLCPUFA在小鼠中的生物可用性和有益的生理作用.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 非常长链多不和脂肪酸 (VLCPUFA) 具有至关重要的生物作用.
- 由于缺乏适合VLCPUFA的饮食来源,研究有限.
- 鱼油是n-3VLCPUFA的潜在来源.
研究的目的:
- 研究一种从鱼油中提取的新型n-3VLCPUFA富油的生物可用性和生理功能.
- 评估VLCPUFA补充剂对小鼠心脏代谢健康和视觉表现的影响.
- 探索VLCPUFA作用背后的分子机制,特别是PPAR激活.
主要方法:
- 从鱼油中生产富含 n-3 C24-28 的 VLCPUFA 油.
- 向C57BL/6J小鼠通过单剂量测试和8周的补充剂给予VLCPUFA油.
- 在血清,肝脏,大脑和眼睛中分析VLCPUFA水平.
- 评估心脏代谢参数,电网膜学和视觉表现.
- 对PPAR信号通路和体外PPAR激活试验的基因表达分析.
主要成果:
- 单剂量测试显著增加了血清和视网膜C24:5水平.
- 八周的补充导致VLCPUFA纳入肝脏,大脑和眼睛.
- 饮食中的VLCPUFA改善了心脏代谢标志物,并增强了电网膜学反应和视觉表现.
- 在PPAR信号通路中,VLCPUFA补充调节基因表达.
- 在实验室中,VLCPUFA-油和C24:5表现出对PPARs有强烈的激活活性.
结论:
- 鱼油衍生的VLCPUFA具有生物可用性,并有效地纳入组织.
- 饮食中的VLCPUFA为小鼠的心脏代谢健康和视力提供了显著的好处.
- VLCPUFAs作为PPAR激动剂,表明它们生理效应的关键机制.
- VLCPUFA-油显示为心脏代谢风险和眼睛健康的补充疗法有前途.
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