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行为成和物质使用障碍之间的大规模功能网络交替的相似性和差异:比较的元分析
Xinglin Zeng1,2, Xinyang Han3, Dong Zheng4
1Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, 999078, China.
Psychological medicine
|December 4, 2023
概括
行为成和物质使用障碍有共同的大脑连接变化,特别是涉及前端对象和其他网络. 还存在明显的变化,可能与特定物质效应有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 行为成 (BA) 和物质使用障碍 (SUD) 具有重叠和独特的临床,认知和行为特征.
- 了解这些相似之处和差异的神经基础对于开发有针对性的干预措施至关重要.
研究的目的:
- 通过使用voxel-wise的元分析,研究BA和SUD之间的静止状态功能连接 (rs-FC) 的常见和明显变化.
- 探索改变的rs-FC模式和两种成类型的临床特征之间的关系.
主要方法:
- 休息状态功能连接 (rs-FC) 的Voxel-wise元分析分别对BA和SUD进行.
- 定量结合分析发现了共同和独特的rs-FC变化.
- 包括92个数据集,包括2444名成患者和2712名健康对照.
主要成果:
- 无论是BA还是SUD,在SN超连接性旁边,在前端平行网络 (FPN) 和其他网络 (DMN,AN,SN) 之间都显示出共同的rs-FC变化.
- 与BA相比,SUD表现出明显的网络内部和网络间的rs-FC变化,主要是在DMN和FPN中,与BA相比.
- 改变的rs-FC与成严重程度 (BA) 和物质使用持续时间 (SUD) 等临床特征相关.
结论:
- 在BA和SUD中常见的rs-FC变化与共享的异常行为有关,如受损的抑制和突出归因.
- 在SUD中明显的rs-FC变化可能反映了物质的特定神经化学作用.
- 研究结果强调了不同类型的成背后的共同和独特的神经机制.
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