基于自然衍生聚合物的双网水凝的最新进展:合成,特性和生物应用
Korina Vida G Sinad1, Ruth C Ebubechukwu1, Crystal K Chu1
1Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania, USA. ckc221@lehigh.edu.
Journal of materials chemistry. B
|December 4, 2023
概括
由蛋白质和多糖类等天然聚合物制成的双网 (DN) 水凝提供了更好的机械强度和稳定性. 本综述探讨了它们的设计,特性和在组织工程和药物输送等领域的应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 材料工程 材料工程 材料工程
背景情况:
- 自然衍生的生物聚合物具有生物相容性,但通常缺乏足够的机械性能,无法用于实际应用.
- 双网络 (DN) 水凝通过结合不同的聚合物网络来增强机械性能和稳定性.
- 最近的进展侧重于基于蛋白质和基于多糖的DN水凝,以提高性能.
研究的目的:
- 审查基于蛋白质和基于多糖的双网络 (DN) 水凝的最新发展.
- 突出设计策略和交叉连接机制,以改善机械性能和材料性能.
- 强调这些先进的水凝在生物领域的多样化应用.
主要方法:
- 对最近开发的基于蛋白质和基于多糖的DN水凝的文献综述.
- 网络结构和交联机制的分析有助于增强属性.
- 根据材料设计和固有的生物聚合物特性对应用的分类.
主要成果:
- 与传统水凝相比,基于蛋白质和基于多糖的DN水凝显示出显著增强的机械性能和稳定性.
- 具体的网络设计和交叉连接策略对于定制材料性能至关重要.
- 这些DN水凝对组织工程,药物输送,生物粘合剂,伤口愈合和可穿戴传感器的应用非常有前途.
结论:
- 基于自然衍生聚合物的DN水凝代表了生物材料开发的重大进步.
- 需要对新型设计原则进行进一步的研究,以克服当前的挑战并扩大其生物应用.
- 这些材料对再生医学和生物医学设备的未来创新有着巨大的潜力.
相关概念视频
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...
Polymers
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Classification and Mechanical Properties of Synthetic Polymers
Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...


