昼夜流行病学:结构疾病的昼夜原因和实际影响
Thomas C Erren1, Peter Morfeld1
1Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Köln, Germany.
Chronobiology international
|December 4, 2023
概括
干扰身体的内部时钟,或时间的破坏,可能会增加癌症的风险. 新的方法量化单个"剂量"的时间干扰更好的流行病学研究昼夜节律和疾病.
科学领域:
- 时间生物学 时间生物学
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 假设身体内部时钟 (昼夜节律) 的干扰会导致包括癌症在内的负面健康结果.
- 尽管有机械学和动物证据,关于轮班工作和昼夜干扰致癌性的流行病学数据仍然有限.
- 现有的研究往往只关注轮班工作,可能忽视昼夜干扰的细微方面.
研究的目的:
- 提出一个新的概念框架,用于昼夜流行病学使用指向非循环图 (DAG).
- 倡导量化个体"剂量"的时间干扰,而不是仅仅依赖轮班工作的暴露.
- 建立生物 (内部) 夜作为未来昼夜流行病学的基本要素.
主要方法:
- 利用定向非循环图 (DAG) 来概念化昼夜干扰中的因果路径.
- 提出了一种方法来量化基于清醒时间和生物夜晚的个体时间干扰剂量.
- 强调了测量依赖时间的个人数据和分析依赖时间的混的挑战.
主要成果:
- 证明轮班工作本身可能是疾病因果关系的暴露变量不足.
- 建议从清醒间隔和生物夜晚的交集中获得的个别时间干扰剂量提供更易于解释的流行病学见解.
- 确定了对先进的测量和分析技术的需求,以捕捉时间依赖的混.
结论:
- 量化个体时间干扰剂量对于推进昼夜流行病学至关重要.
- 生物夜晚是理解昼夜干扰对健康影响的关键指标.
- 未来的研究需要复杂的方法来准确地测量和分析时间依赖的数据,以获得可靠的流行病学发现.
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