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Updated: Jul 22, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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在人类Chk1,Chk2和Wee1蛋白激酶中发现的有害突变的基和基于结构的评估

Venessa Colaco1, Nabajyoti Goswami1, Vijay Kumar Goel2

  • 1Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra, India.

Journal of cellular biochemistry
|December 4, 2023
PubMed
概括

这项研究确定了检查点激酶Chk1,Chk2和Wee1中的致病突变,这对DNA损伤反应至关重要. 这些变异影响蛋白质结构和功能,为癌症管理提供潜在的治疗点.

关键词:
在 Chk1 上,你会看到 Chk1 的位置.在 Chk2 中使用 Chk2.在 silico 工具.模拟MD的模拟方法一个小小的小小的.误解突变是一种错误的突变.

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