增强基于黄素的离子液体脂质体的通过皮肤传递,用于牛皮的应用
Beibei Lu1,2,3,4,5, Jianglin Zhang1,2,3, Jiaheng Zhang4,5
1Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
ACS applied bio materials
|December 4, 2023
概括
我们开发了一种基于黄素的离子液体脂质体 (Cur-Bet-IL-Lip),以增强黄素的输送. 这种配方显示皮肤透和细胞吸收的改善,为治疗炎症性皮肤疾病提供了潜在的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 皮肤病学 皮肤病学
背景情况:
- 黄素是一种天然化合物,具有有限的溶解性和皮肤透性.
- 离子液体和脂质体为药物递送增强提供了潜力.
- 开发有效的药物输送系统对于溶性较差的药物至关重要.
研究的目的:
- 为了合成和描述基于黄素的离子液体脂质体 (Cur-Bet-IL-Lip).
- 为了评估Cur-Bet-IL-Lip的皮肤透和细胞吸收.
- 评估Cur-Bet-IL-Lip对角质细胞的抗炎作用.
主要方法:
- 基于黄素的离子液体 (Cur-Bet-IL) 的制备及其随后的脂质体配方 (Cur-Bet-IL-Lip).
- 对Cur-Bet-IL-Lip稳定性和生物相容性的评估.
- 在体外皮肤透研究通过角层.
- 对 HaCaT 细胞的细胞吸收和抗炎作用 (细胞因子和原表达) 的评估.
主要成果:
- 库尔-贝特-IL-Lip表现出良好的稳定性和生物相容性.
- 在24小时内通过皮肤达到49%的累积黄素透.
- 与Cur-Bet-IL相比,HaCaT细胞的吸收率高出1.87倍.
- 显著减少了促炎性细胞因子 (TNF-α,IL-1β,IL-17A,IL-17F,IL-22) 和增加了原I表达.
结论:
- Cur-Bet-IL-Lip有效地提高了黄素的溶解性和皮肤透性.
- 该配方表现出强大的抗炎性质,并促进原蛋白合成.
- Cur-Bet-IL-Lip对黄素的临床应用具有显著的潜力,特别是对于不溶性药物.
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