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脑下垂体瘤与细胞外延伸的形态分类

Sauradeep Sarkar^1,2, C Eduardo Corrales³, Edward R Laws¹

¹Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

|December 4, 2023

概括

狭垂体腺瘤 (2B型) 与手术结果较差和并发症增加有关. 使用圆顶与部比率 (D/Nr) 的术前分类有助于预测内透膜切除的结果.

科学领域:

神经外科神经外科
内分泌学在内分泌学.
放射学放射学是一门学科.

背景情况:

带有超细胞延伸的垂体宏腺瘤带来了外科手术的挑战.
形态参数可以影响外科手术的结果.

研究的目的:

为了研究形态参数和手术结果之间的关系,在垂体腺瘤与超细胞扩展.
评估手术前瘤分类的临床相关性.

主要方法:

160名接受内镜式透切除的患者的MRI分析.
根据形状和圆顶到部的比例 (D/Nr) 将瘤分为1型,2A型和2B型.
手术结果和并发症的后勤回归分析.

主要成果:

2B型瘤与较低的切除程度 (EOR) 和较高的残留瘤率有关.
2B型瘤与手术内脑脊髓液泄漏和手术后无味糖尿病增加相关.
瘤亚型显著影响了瘤大小,EOR,残留瘤和并发症.

结论:

使用D/Nr进行手术前分类对于垂体腺瘤具有临床意义.
2B型宏瘤预测总切除率较低和术后并发症较高.
这种分类有助于进行内镜透切除的手术规划和结果预测.

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The Pituitary Gland

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.