从2010年到2022年的临床批准的抗生素
1University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich. erik.jung@chem.uzh.ch.
Chimia
|December 4, 2023
概括
本综述涵盖了2010年至2022年间批准的小分子抗生素. 它详细介绍了合成抗生素,天然产品衍生品和天然产品,强调了这一时期的关键药物批准.
科学领域:
- 药理学和传染病的研究
- 药物发现和开发 药物发现和开发
背景情况:
- 在2010-2022年期间,在开发新型小分子抗生素方面取得了重大进展.
- 抗微生物耐药性需要不断引入新的治疗剂.
- 小分子抗生素是对抗细菌感染的关键药物类别.
研究的目的:
- 审查和分类从2010年到2022年批准临床使用的小分子抗生素.
- 提供不同类别新批准的抗生素的概述.
- 记录可用于治疗传染病的治疗剂.
主要方法:
- 对抗生素的监管批准的文献审查.
- 经批准的药物根据其来源进行分类 (合成,天然产品衍生品,天然产品).
- 对药物批准的时间框架的分析.
主要成果:
- 批准了四种合成抗生素:贝达基林,普雷托曼尼德,德拉弗洛克萨辛和特迪索利德.
- 九种天然产品衍生品获得批准,包括塞法托林 (ceftaroline) 福萨米尔 (fosamil),塞菲德罗科尔 (cefiderocol),血素 (plazomicin),奥马达环素 (omadacycline),埃拉瓦环素 (eravacycline),沙利环素 (sarecycline),莱法穆林 (lefamulin),达尔巴万辛 (dalbavancin) 和奥里塔万辛 (oritavancin).
- 在此期间,批准了一种天然产品抗生素fidaxomicin.
结论:
- 在2010-2022年期间,各种各样的小分子抗生素进入临床使用.
- 批准的药物包括新型合成化合物和现有天然产品的修改.
- 这些批准为各种细菌感染提供了新的治疗选择.
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