走向数字实验室的艰难道路
Peter Sagmeister1,2, Jason D Williams3,2, C Oliver Kappe4,2
1Center for Continuous Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering (RCPE), Inffedgasse 13, 8010 Graz. peter.sagmeister@rcpe.at.
Chimia
|December 4, 2023
概括
智能制造通过连续制造和数字化加速制药生产. 具有实时分析的自动流体化学平台,可实现对活性药物成分 (API) 的自我优化和先进的过程控制.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 化学工程是化学工程的重要组成部分.
- 过程化学 过程化学
背景情况:
- 制药行业正在向活性药物成分 (API) 的连续制造过渡.
- 数字化,过程分析技术 (PAT) 和数据丰富的实验是智能制造的关键推动因素.
- 这些技术的早期实施对于高效的发展至关重要.
研究的目的:
- 介绍实现实时过程分析的自动流化学反应堆平台的关键方面.
- 突出这些平台在加速智能制造路线方面的潜力.
- 展示诸如自我优化和自动化模型构建等功能.
主要方法:
- 实现自动化流量化学反应堆平台.
- 集成实时过程分析技术 (PAT).
- 利用数字化和数据丰富的实验.
主要成果:
- 证明了API合成自动化流体化学的可行性.
- 展示了平台进行自我优化和自动化反应模型构建的能力.
- 强调了实施先进的过程控制策略的潜力.
结论:
- 具有实时分析的自动流化学平台对于智能制药制造至关重要.
- 这些系统有助于加快合成路线的开发和优化.
- 数字化和PAT的整合使API生产更加有效和可控.
相关概念视频
01:13Data Collection by Experiments
Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public clinical trial...
An example of the experimental method is a public clinical trial...
01:30Machines: Problem Solving II
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. Consider a lifting tong carrying a 100 kg load. It comprises movable sections DAF and CBG linked together with member AB.