伊利利利利和公司的流量化学的历史
Martin D Johnson1, Timothy Braden2, Joel R Calvin3
1Eli Lilly and Company, Process Development, Indianapolis, Indiana 46285. JOHNSON_MARTIN_D@LILLY.COM.
Chimia
|December 4, 2023
概括
流化学加速了早期物质的输送,并使危险反应的安全扩展成为可能. 最近的进步允许使用小体积连续 (SVC) 工艺连续制造强大的色分子.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 过程化学 过程化学
- 有机合成 有机合成
背景情况:
- 流化学最初是针对开发实验室中早期材料交付的速度.
- 它使化学转化难以或不安全进行批量加工的规模化成为可能.
- 早期的应用包括纽曼四重排,克莱森重排,水合甲基化和热性伊米达循环.
研究的目的:
- 为了展示流体化学的演变和扩展应用.
- 突出其在安全扩大危险反应中的作用.
- 展示用于强分子生产的连续制造的最新进展.
主要方法:
- 利用流体化学来扩大具有挑战性的反应.
- 应用流体化学,用于安全制造危险工艺.
- 实施小体积连续 (SVC) 工艺,用于产生强大的色分子.
主要成果:
- 由于安全问题,成功地缩放了不能在批量中进行的反应.
- 实现了危险化学品的安全工业规模生产,如高压化和格林纳德反应.
- 在~10公斤/天的速度实现了强大的解分子的连续生产,整合了反应,提取,蒸和结晶.
结论:
- 流化学已经从快速物料输送的工具演变为安全高效的化学制造的关键技术.
- 它的应用范围扩展到危险反应和持续生产高价值的制药化合物.
- 小体积连续 (SVC) 工艺代表了制药制造业的重大进步,特别是对于强效分子.
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