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细胞质蛋白的DNA Aptamer 结合性八重复区域

Jing Sheng1,2, Nan Zhang1, Zhenhao Long1,2

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Bio-systems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Analytical chemistry
|December 4, 2023
PubMed
概括

细胞质蛋白 (PrPC),在瘤中发现并与神经退行性疾病有关,是由DNA受体 (HA5-68) 准的. 这种胺酶结合了八个的重复区域,有助于PrPC的检测和潜在的治疗开发.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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