基于基因组技术的整合性方法在功能性研究中的增强剂
Qilin Wang1,2, Junyou Zhang1,2, Zhaoshuo Liu1,2
1School of Engineering Medicine, Beihang University, Beijing 100191, China.
Briefings in bioinformatics
|December 4, 2023
概括
研究人员正在探索非编码DNA增强剂,使用先进的omics方法和机器学习. 本综述详细介绍了整合复杂基因组数据的方法,以了解增强器功能和监管机制.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 称为增强剂的非编码DNA元素在基因转录中起着至关重要的作用.
- 尽管已识别了数千种,但大多数人类基因组增强剂缺乏明确的功能,目标或监管机制.
- 高通量测序和奥米克技术对于增强器研究至关重要.
结论:
- 本综述为使用多omics数据集成分析增强剂提供了全面的基础.
- 它强调了先进的计算方法的潜力,以阐明增强器功能和监管网络.
- 了解增强剂对于推进生物医学等领域至关重要.
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