循环节障碍通过损害内皮功能来诱导勃起功能障碍.
Tao Li1,2, Yi-Ting Jiang3, Xin-Zhu Qi4
1Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Asian journal of andrology
|December 4, 2023
概括
在老鼠中,循环节律的干扰会通过影响氧化通路和内皮健康,损害勃起功能. 这项研究强调了光暗周期中断与勃起功能障碍之间的联系.
科学领域:
- 生理学 生理学 生理学
- 时间生物学 时间生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 循环节律调节了许多生理过程. 这些节律的破坏越来越多地与各种健康问题有关.
- 勃起功能是一个复杂的生理过程,受到血管和神经因素的影响,可能容易受到昼夜干扰的影响.
研究的目的:
- 在大鼠模型中研究改变光暗周期对勃起功能的影响.
- 分析昼夜干扰对体内氧化物生产中的关键酶和分子表达的影响.
- 探索勃起组织中核心昼夜钟基因的破坏.
主要方法:
- 成年雄性大鼠被暴露在不同的光/黑暗条件下:对照,恒定黑暗 (DD),恒定光 (LL) 和转移周期 (DL).
- 通过测量最大洞内压力 (mICP) 和mICP/平均动脉压 (MAP) 的比率来评估勃起功能.
- 身体洞穴组织分析了信使RNA (mRNA) 和内皮氧化合成酶 (eNOS),神经元氧化合成酶 (nNOS) 和核心昼夜钟组件 (例如,钟,BMAL1,PER1,PER2,PER3,CRY1,CRY2) 的蛋白质水平.
主要成果:
- 与对照组相比,暴露在DD,LL和DL条件下的老鼠表现出明显减少的勃起功能.
- LL和DL组显示 eNOS 减少,而DD,LL和DL组显示在mRNA和蛋白质水平上减少了nNOS表达.
- 氧化物 (NO) 和循环瓜诺辛单酸盐 (cGMP) 的产生受到抑制,并且 PER1,PER3,CRY1和CRY2等昼夜基因的表达在受影响组的 corpora cavernosa 中发生了改变.
结论:
- 循环节障碍会对勃起功能产生负面影响,可能是通过内皮功能受损和氧化信号减少.
- 核心昼夜时钟元素存在于洞穴体中并被破坏,这表明它在调节勃起功能方面发挥着直接作用.
- 需要进一步的研究来阐明个体昼夜元素影响勃起功能的具体机制.
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