在HIV-1精英控制者中,自然杀手细胞和树突细胞之间的依赖IL-15的免疫交叉交叉
Ciputra Adijaya Hartana1, Melanie Lancien1, Ce Gao1
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Cell reports
|December 4, 2023
概括
精英HIV-1控制者的自然杀手 (NK) 细胞因表观遗传变化而对IL-15表现出增强的反应. 这种先天性免疫细胞交叉声可以在没有药物的情况下改善HIV-1的控制.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 自然杀手 (NK) 细胞是关键的先天性免疫效应体.
- NK细胞可以通过免疫介导机制控制HIV-1的复制.
- 精英控制器 (EC) 在没有抗逆转录病毒治疗的情况下自然抑制HIV-1.
研究的目的:
- 研究HIV-1精英控制器中细胞毒性NK (cNK) 细胞的表观遗传修饰和功能特征.
- 阐明介素-15 (IL-15) 信号传递和免疫细胞交叉对自然HIV-1控制中的作用.
主要方法:
- 在cNK细胞中激活和抑制色素特征的全基因组评估.
- 对IL-2/IL-15受体β链和BCL2基因位点修改的分析.
- 评估状树突细胞对IL-15和IL-15转录的cNK细胞反应.
- 对cNK细胞的代谢概况.
主要成果:
- 来自EC的cNK细胞在IL-2/IL-15受体β链和BCL2位点表现出增加的激活基因素修饰.
- 这些表观遗传变化增强了cNK细胞对IL-15的反应能力.
- 在ECs中的髓状树状细胞显示出更高的IL-15转录,促进免疫交叉交流.
- 增强的IL-15信号传递促进了cNK细胞的生存,细胞毒性和糖性代谢特征.
结论:
- ECs在其cNK细胞中显示出明显的IL-15反应特征,由表观遗传修饰驱动.
- 天生的免疫路径,特别是IL-15介导的髓状树突细胞和cNK细胞之间的交叉声,对于自然的,无药的HIV-1控制至关重要.
- 这些发现突显了针对先天免疫力来治疗HIV-1病毒的潜力.
相关概念视频
Immune Response Against Viral Pathogens
790
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
790
T Cell Activation and Clonal Selection
743
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
743
Cytotoxic T Cells-mediated Immune Response
923
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
923
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Antigens Involved in Adaptive Immunity
502
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
502


