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七种鱼类中PPD-昆毒性的物种间差异:代谢物识别和半量化

David Montgomery1, Xiaowen Ji2,3, Jenna Cantin1

  • 1Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3, Canada.

Environmental science & technology
|December 4, 2023
PubMed
概括

有毒的轮胎化学物质N-(1,3-Dimethylbutyl) -N'-phenyl-p-phenylenediamine-quinone (6PPD-Q) 显示出不同的鱼类毒性. 耐受性物种会分泌更多的6PPD-Q代谢物,这表明排毒差异会导致敏感性.

关键词:
特定物种毒性 特定物种毒性生物转化过程中的生物转化.高分辨率质谱学高分辨率质谱学代谢物识别 代谢物识别预测性毒理学 预测性毒理学

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