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可重复使用的Zwitterionic多孔有机聚合物用于血清中的胆红素去除

Qingsi Li¹, Yingnan Zhu², Yongjian Li³

¹Department of Biochemical Engineering, School of Chemical Engineering and Technology, Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), Tianjin University, Tianjin 300350, China.

ACS applied materials & interfaces

|December 4, 2023

概括

菌性多孔有机聚合物 (POPs) 提供了一种可重复使用和高效的解决方案,用于在血液输液中去除胆红素. POP-CB-40%显著增强了胆红素吸收的46.5倍,显示出更好的血红相容性.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
聚合物化学聚合物化学

背景情况:

胆红素积累是肝脏疾病的一个关键问题,需要有效的输血疗法.
多孔有机聚合物 (POP) 作为吸附剂具有前景,但需要提高血红相容性和效率.
开发生物相容和可重复使用的吸附剂对于临床血 perfusion 应用至关重要.

研究的目的:

设计和合成可重复使用,血液兼容和高效的胆红素吸收剂,使用zwitterionic-modified多孔有机聚合物 (POPs).
为了评估不同的zwitterionic模块 (carboxybetaine甲基酸盐,sulfobetaine甲基酸盐和2-methacryloyloxyethyl phosphorylcholine) 对POP特征和性能的影响.
通过评估胆红素吸附能力,血红相容性和可重复使用性来证明这些zwitterionic POPs在输血治疗中的潜力.

主要方法:

合成多孔有机聚合物 (POP) 并用三种不同的zwitterion进行修改:碳素贝他因甲基酸盐 (CB),硫贝他因甲基酸盐 (SB) 和2-methacryloyloxyethyl phosphorylcholine (MPC).
研究了不同的zwitterion整合百分比对POP特性的影响,包括水友性,蛋白质耐药性和胆红素吸附性.
评估了血清中兹维特里昂性POPs的血红相容性和胆红素吸附效率,并评估了它们在多个周期中的可重复使用性.

主要成果:

兹维特里昂基基基改造显著改善了POPs的血液相容性,水友性和胆红素吸收能力.
在100%血清中,POP-CB-40%表现出最高的胆红素吸收,与100%血清中的非zwitterionic POP相比,显著增加了46.5倍.
提高POP-CB-40%的性能是由于其在生物环境中提高了水友性和蛋白质耐受性.
POP-CB-40%显示出优异的可重复使用性,在100%血清中经过五个循环循环后,保持大约99%的胆红素吸收能力.

结论:

兹维特里昂基基改造是一种可行的策略,可以基于多孔有机聚合物制造出高效且可重复使用的胆红素吸收剂.
由于其优越的胆红素吸附性,血液相容性和可重复使用性,POP-CB-40%代表了血液输血应用的有希望的候选者.
这项研究为设计用于临床输血治疗的先进生物相容性POP基吸附剂提供了宝贵的指南.

关键词:

吸附吸附是一种吸附.胆氨酸是什么意思?胆氨酸是什么意思血 perfusion 输血输血输血输血输血多孔有机聚合物的有机聚合物.采用了zwitterionic材料的使用方法.

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