类风湿性关节炎,细膜肺的定量特征和吸烟者的死亡率
Gregory C McDermott1,2, Keigo Hayashi1, Kazuki Yoshida1,2
1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.
Rheumatology (Oxford, England)
|December 4, 2023
概括
吸烟者的类风湿性关节炎 (RA) 与更多的肺间歇性变化有关. 结合RA和肺气显著增加了5倍以上的死亡风险.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 类风湿病学 类风湿病学
背景情况:
- 在类风湿性关节炎 (RA) 中,关于定量CT (QCT) 肺部特征的研究有限.
- 了解这些特征的患病率和对RA患者死亡率的影响至关重要.
研究的目的:
- 在RA患者中调查QCT副瘤肺部特征的患病率.
- 检查QCT特征与RA和非RA参与者的死亡率之间的关联.
主要方法:
- 利用了COPDGene研究的数据,这是一个多中心的吸烟者队列.
- 在高分辨率的CT扫描中采用k-最近邻方量化,以评估肺部百分比,间歇性变化和肺瘤.
- 分析了使用多变量线性回归和Cox回归的死亡风险的关联,评估了统计相互作用.
主要成果:
- RA 与更高的间歇性肺部变化百分比相关 (β=1.7,P=0.0008).
- 在RA和肺气之间没有发现显著的关联 (β=1.3,P=0.44).
- 与非RA和RA参与者相比,RA和肺气 (>75百分位) 的参与者面临的死亡风险增加了5倍以上,而非RA和RA参与者患肺气较少.
结论:
- 吸烟者的RA与增加的间歇性肺部变化有关.
- RA 和肺气的结合显著增加了死亡风险,这表明了关键的相互作用.
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