MamoRef:使用全场CW扩散反射的光学乳房学装置. 呈现,验证和初步临床结果
Nicolás A Carbone1,2, Demián A Vera1, M Victoria Waks-Serra1
1Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires (CIFICEN, UNCPBA-CICPBA-CONICET), Argentina.
Physics in medicine and biology
|December 4, 2023
概括
使用近红外光的新型乳腺癌查设备MamoRef,通过测量血红蛋白度和氧和度来区分病变,显示出有前途. 这种便携式,不压缩的工具提供了补充诊断信息.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 乳腺癌的诊断 乳腺癌的诊断
背景情况:
- 目前的乳腺癌查方法有局限性.
- 需要补充诊断工具,提供额外的生理信息.
- 近红外 (NIR) 谱学为非侵入性组织分析提供了潜力.
研究的目的:
- 介绍了MamoRef原型的设计和开发,这是一种新型的乳房学装置.
- 验证MamoRef.的理论重建算法和硬件设计.
- 评估MamoRef在乳腺疾病患者的临床可行性和诊断潜力.
主要方法:
- 开发一个MamoRef原型,使用低功率连续波激光和CCD摄像机.
- 通过蒙特卡洛模拟进行验证,以评估重建算法的准确性.
- 幻影实验以确认硬件功能.
- 启动与乳腺疾病患者的临床可行性研究.
主要成果:
- 蒙特卡洛模拟显示了染色体度差异的有效恢复,与地面真相有很高的相关性 (SSIMs ≥0.8).
- 幻影实验验证了MamoRef硬件实现的有效性.
- 最初的临床发现表明,MamoRef在区分乳腺病变方面具有有前途的能力.
结论:
- MamoRef是乳腺病理学查的一个有前途的进步,为标准技术提供了补充信息.
- 该设备准确地确定氧/脱氧血红蛋白度和氧和度.
- MamoRef是便携式的,相对便宜的,不需要进行乳房压缩,从而提高了其临床实用性.
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