血清型3抗体反应和抗体功能与血清型19A相比,在儿童接受13-valent肺炎球菌结合体免疫接种后
Naoko Fuji1, Minh Pham2, Ravinder Kaur1
1From the Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, 1425 Portland Ave, Rochester, New York.
The Pediatric infectious disease journal
|December 4, 2023
概括
与19A血清型相比,13性肺炎球菌合疫苗 (PCV13) 对血清型3的有效性较低. 对3型血清体的抗体水平不足以防止急性中耳炎和幼儿殖民.
科学领域:
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 13肺炎球菌合疫苗 (PCV13) 对于预防儿童肺炎球菌感染至关重要.
- 有关PCV13的可变有效性存在担忧,特别是与Streptococcus pneumoniae血清型3相比,与血清型19A相比.
研究的目的:
- 为了比较PCV13免疫接种后的IgG和功能性抗体对3和19A血清型的反应.
- 为了评估PCV13诱导的抗体水平与自然获得的免疫.
- 评估PCV13在预防急性中耳炎 (AOM) 和3类和19A类血清型的殖民性方面在6-36个月龄的儿童中的有效性.
主要方法:
- 在纽约罗切斯特进行的前性纵向观察队列研究.
- 通过培养检测肺炎球菌;用ELISA测量血清抗体水平.
- 功能性抗体和狂热度分别通过松细胞酶试验和硫酸盐键破坏进行评估.
- 通过比较AOM和殖民化的疫苗接种前和后血清型患病率来评估PCV13的有效性.
主要成果:
- 在PCV后的血清型19A的儿童中,获得保护性抗体值 (≥0.35μg/mL) 的比例高于PCV后的血清型3的儿童.
- 只有19A血清型显示PCV13诱导的opsonophagocytosis标位和抗体激烈度显著增加.
- 虽然自然诱导的免疫对3型血清体呈现出随着年龄增长的积极趋势,但PCV13诱导的免疫没有.
- PCV13的有效性已被证实用于预防AOM和殖民化的血清型19A,但不是用于血清型3.
结论:
- 与19A血清型相比,PCV13引起较低的抗体水平,并且对血清型3的有效性较低.
- 在大多数幼儿中,PCV13后的血清型3抗体水平似乎不足以提供足够的保护,防止AOM和殖民.
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