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通过7-deazaadenosine和链接器修改,增强尼古丁胺N-甲基转移酶双基质抑制剂活性

Pengyu Li1, Cuicui Xia2, Xiangqian Kong1

  • 1State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, Guangzhou 510530, China; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.

Bioorganic chemistry
|December 4, 2023
PubMed
概括

研究人员通过修改腺的N7位置来开发出强大的尼古丁胺N-甲基转移酶 (NNMT) 抑制剂. 化合物3-12显示出强烈的抑制活性和选择性,为NNMT药物开发提供了新的见解.

关键词:
亚丁氨酸修饰的修改双基质抑制的抑制作用尼古丁胺N-甲基转移酶的使用这是一种S-adenosylmethionine.

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