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具有NIR反应的注射性酸骨水泥装载着伊卡林可促进骨质生成

Bin Wang¹, Yanbin Zhao², Yangyang Li²

¹Department of Orthopedics, Jingling Hospital, Medicine College, Nanjing University, Nanjing, 210002, Jiangsu, China.

Journal of the mechanical behavior of biomedical materials

|December 4, 2023

概括

这项研究通过结合含有icariin的纳米粒子和酸来增强酸骨水泥 (MPC). 改性骨水泥 (IHP-CA MPCs) 显示了用于骨植入物的改进性质.

科学领域:

生物材料科学生物材料科学
整形外科工程整形外科工程
药物输送系统药物输送系统

背景情况:

传统的酸骨水泥 (MPC) 具有诸如骨质生成受限和药物快速释放等局限性.
这些缺点阻碍了MPC作为骨植入物的临床疗效.

研究的目的:

开发一种改进的酸骨水泥 (MPC),具有增强的骨质生成特性和受控的药物释放.
解决传统的MPCs的局限性,以便在骨再生中获得更好的临床应用.

主要方法:

伊卡林被装入与多多巴胺修改的中孔性纳米二氧化容器中.
这些修改后的容器和酸被纳入酸骨水泥中,以创建IHP-CA MPC.

主要成果:

开发的IHP-CA MPCs显示了延长的固化时间,接近中性的pH值,以及优越的注射性和压力强度.
在体外研究证实了改造的MPCs的优良生物相容性和显著的骨质促进能力.

结论:

新的IHP-CA MPC配方为克服传统MPC的局限性提供了一个有希望的解决方案.
这些发现为先进的MPCs在骨缺陷修复和再生中的临床使用提供了宝贵的见解和参考.

关键词:

伊卡里恩是什么意思酸是酸的骨头水泥骨头水泥.半孔的二氧化纳米粒子.接近红外的响应骨质发生过程 (osteogenesis)

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