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在局部高级直肠癌的新辅助疗法后,二次癌症的发生率

Praachi Raje¹, Swati Sonal¹, Chloe Boudreau²

¹Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

The Journal of surgical research

|December 4, 2023

概括

针对局部晚期直肠癌 (LARC) 的新辅助化学辐射不会增加二次癌症的风险. 这种治疗甚至可能对盆腔器官癌症产生保护作用,这需要进一步研究.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
手术瘤学手术瘤学

背景情况:

在局部晚期直肠癌 (LARC) 新辅助化学辐射后发生二次癌症的风险是正在进行的辩论的主题.
这项研究调查了接受新辅助治疗的LARC患者中二次恶性瘤的发生率.

研究的目的:

为了确定LARC的新辅助化学辐射是否与二次癌症风险增加有关.
评估新辅助疗法对骨盆器官的潜在局部保护作用.

主要方法:

一项回顾性队列研究比较了364名接受新辅助辐射 (传统或短期) 随后切除的LARC患者和142名没有接受新辅助辐射的手术切除的患者.
二次性癌症被定义为非转移性,非结肠直肠恶性瘤,在治疗后或切除后至少6个月诊断出来.

主要成果:

在新辅助辐射组 (9.3%) 和对照组 (10.6%) 之间,二次癌症的发生率相似.
接受新辅助放射治疗的患者患盆腔器官癌症的风险显著降低 (OR 0.18;P=0.02).
在患有二次癌症的患者中,没有发现遗传突变或癌症综合征.

结论:

对LARC的新辅助化学辐射与二次癌症风险增加无关.
这些发现表明,新辅助化学辐射对骨盆器官,特别是前列腺有潜在的局部保护作用.
持续的长期跟踪对LARC患者的持续风险评估至关重要.

关键词:

新辅助剂辐射的使用前列腺癌是什么意思前列腺癌是什么意思保护性保护性保护性这是直肠癌.二次性癌症二次性癌症

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