韦尼克斯·卡塞奥萨 (Vernix caseosa) 揭示了机械学线索,将母亲肥胖与亚托皮炎病原体联系起来
Carolina Cabalín1, Marisol Dibarrart1, Juan José Núñez-Rosales1
1Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
The Journal of allergy and clinical immunology
|December 4, 2023
概括
孕妇超重和怀孕期间的肥胖与婴儿亚托皮炎 (AD) 有关. 来自这些婴儿的Vernix caseosa (VC) 显示了皮肤屏障蛋白和微生物组的改变,这表明早期的AD风险因素.
科学领域:
- 皮肤病学 皮肤病学
- 新生儿研究新生儿研究
- 微生物组研究 微生物组研究
背景情况:
- 孕产妇超重/肥胖与婴儿类皮肤炎 (AD) 有关,但机制尚不清楚.
- 胎儿皮肤涂层Vernix caseosa (VC) 可能反映出子宫内的发育变化.
- 在超重/肥胖母亲的新生儿中研究VC可能会揭示AD容易发生的胎儿皮肤变化.
研究的目的:
- 为了比较AD生物标志物和葡萄球菌载荷在VC的后代超重/肥胖 (O/O) 的母亲与正常体重的母亲.
- 根据母亲怀孕前的体重,识别新生儿患阿兹海默症风险的早期指标.
主要方法:
- 从14岁的新生儿和12名正常体重的母亲出生后立即收集的VC.
- 使用ELISA的定量化生物标志物和通过定量PCR的葡萄球菌物种.
主要成果:
- 来自O/O组婴儿的VC显示皮肤屏障蛋白减少 (菲拉格林,洛里克林) 和炎症标志物增加 (TSLP,IL-25,IL-33).
- 在O/O组VC中发现了较低水平的共生细菌 (Staphylococcus epidermidis,S. hominis).
- 一年后婴儿AD发病率在O/O组中较高,与VC中的 filaggrin和S. epidermidis减少有关.
结论:
- 从怀孕前超重/肥胖的母亲获得的新生儿VC表现出皮肤屏障功能的分子变化.
- 在VC中的葡萄球菌失生症表明早期的机械联系与后代的AD风险增加.
- 病毒细胞分析提供了关于胎儿皮肤发育和与母亲体重相关的AD倾向的见解.
关键词:
亚托邦性皮肤炎 (Atopic Dermatitis) 是一种不良的疾病.斯塔菲洛科克斯 (Staphylococcus epidermidis) 是一种表皮菌.这种病原体是Staphylococcus hominis.这种疾病叫做dysbiosis.菲拉格林 (Filaggrin) 是一个孕产妇的肥胖症 孕产妇的肥胖症皮肤障碍物 皮肤障碍物胸膜流体的淋巴发育蛋白.维尼克斯卡塞奥萨 (Vernix Caseosa) 是一个更多相关视频
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