衰老和维生素D状况与全身氧化生产和内皮功能标记物的关联
Mario Siervo1, Azizah Mat Hussin2, Patrizia Calella3
1School of Population Health, Curtin University, Perth, WA, Australia; Curtin Dementia Centre of Excellence, Enable Institute, Curtin University, Perth, WA, Australia.
The Journal of nutrition
|December 4, 2023
概括
衰老会减少氧化 (NO) 的产生,但维生素D水平似乎不会影响健康个体的NO合成或内皮功能 (EF). 然而,维生素D与老年超重女性的氧化应激有联系.
科学领域:
- 心血管生理学心血管生理学
- 营养生物化学 营养生物化学
- 衰老研究研究 衰老研究
背景情况:
- 衰老和维生素D缺乏与氧化 (NO) 合成的减少和内皮功能 (EF) 的受损有关,尽管人类的证据有限.
- 研究衰老,维生素D状态和NO/EF生物标志物之间的关系对于了解心血管健康至关重要.
- 之前的研究表明存在潜在的联系,但缺乏可靠的人类数据.
研究的目的:
- 评估年龄,性别和血维生素D度与NO合成和EF生物标志物的相关性.
- 为了比较年轻人与老年健康成年人的NO生产和EF标志物 (研究1).
- 评估这些关联在超重和肥胖的绝经后女性 (研究2).
主要方法:
- 两项横截面研究涉及健康的年轻人/老年人以及超重/肥胖的绝经后女性.
- 测量包括血压,脉冲波速度 (PWV) 和全身NO生产,使用稳定同位素方法.
- 评估了25-基维生素D (25(OH) D),酸盐,酸盐,ADMA和其他相关生物标志物的血度.
主要成果:
- 较年长的参与者与年轻的参与者相比,全身NO的产量显著降低 (P=0.01).
- 血25(OH) D在研究1中与PWV或NO产生无关,但在研究2中与氧化应激标志物3-NT相反相关 (r=-0.31,P=0.004).
- 在这两项研究中,年龄与ADMA (内皮功能障碍的标志物) 呈正相关性 (研究1:r=0.35,P=0.03;研究2:r=0.22,P=0.04).
结论:
- 高龄化独立地与减少的NO产量有关.
- 在这些人群中,血维生素D水平似乎不是NO合成或内皮功能的重要决定因素.
- 在绝经后超重女性中观察到维生素D和氧化应激之间的潜在联系.
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