从急性COVID-19感染中康复后的男性下腺症:一项前性观察性研究
Aravind Prasad1, K G Rashmi1, Jayaprakash Sahoo1
1Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
概括
COVID-19幸存者可能会经历阴性腺和塞尔托利细胞功能障碍. 虽然丸激素水平可以恢复,但很大一部分男性在感染后12个月内表现出持续的低丸激素水平,这表明HPG轴对长期的影响.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 男人的健康 男人的健康
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可以影响下丘脑-垂体-淋巴腺 (HPG) 轴.
- 由SARS-CoV-2引起的 ангиотензин转化酶2 (ACE2) 受体表达与HPG轴中断有关.
研究的目的:
- 为了确定男性COVID-19幸存者中阴性恋的患病率.
- 在COVID-19康复后评估男性的塞尔托利细胞功能障碍.
- 为了评估COVID-19幸存者中HPG轴的恢复.
主要方法:
- 在急性COVID-19感染后对男性受试者的前性观察.
- 低阴性体的生物化学定义:血清丸激素<230 ng/dL或计算的自由丸激素 (CFT) <6.4 ng/mL (总丸激素为230-320 ng/dL).
- 塞尔托利细胞功能障碍定义为inhibin-B <54.5 pg/mL;12个月后对HPG轴恢复进行随访.
主要成果:
- 在平均120天的康复后评估的71名受试者中,24.71%的丸激素低,而19.71%的抑制蛋白-B低.
- 低丸激素在年轻男性 (平均年龄为43.29岁) 和BMI较高的男性中更为普遍.
- 在12个月后,50%的初始低丸激素的受试者仍然表现出持续的低水平,暗示着低球症.
结论:
- 在男性中,COVID-19感染可能导致阴性腺和塞尔托利细胞功能障碍.
- 虽然发生了一些丸激素恢复,但很大一部分幸存者经历了持续的低丸激素.
- 这些发现强调了需要长期监测和管理COVID-19男性幸存者的HPG轴功能.
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