线粒体质量控制:其在代谢功能障碍相关的脂肪性肝病 (MASLD) 中的作用
Soyeon Shin1, Jaeyoung Kim1, Ju Yeon Lee1
1Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Journal of obesity & metabolic syndrome
|December 4, 2023
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越常见. 这篇评论强调了线粒体功能障碍是如何驱动MASLD的,并探讨了有希望的线粒体向治疗方法来对抗这种肝脏疾病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 线粒体生物学 线粒体生物学
- 代谢疾病 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD),以前是非酒精性脂肪性肝病,正在迅速上升,与肥胖和胰岛素抵抗有关.
- 线粒体在肝脏新陈代谢和能量生产中发挥着至关重要的作用,使它们成为MASLD发展的核心.
- 功能障碍的线粒体有助于关键的MASLD病理,包括脂质积累,炎症和肝纤维化.
研究的目的:
- 审查线粒体在MASLD病变发生中的中心作用.
- 探索针对MASLD中线粒体功能障碍的当前和新兴治疗干预措施.
主要方法:
- 文献综述侧重于线粒体在MASLD中的作用.
- 对正在进行的新疗法临床试验和临床前研究进行分析.
- 检查线粒体动态和MASLD易感性之间的遗传关联.
主要成果:
- 线粒体功能障碍是MASLD肝硬化症,炎症和纤维化的关键驱动因素.
- 临床试验显示了诸如维生素E,甲胺和GLP-1受体激动剂等疗法的前景.
- 临床前研究表明,新型药物 (NAD+前体,urolithin A,spermidine,mitoquinone) 可以改善线粒体功能并减少MASLD标记物.
结论:
- 线粒体功能障碍是MASLD发展和进展的组成部分.
- 准线粒体通路为MASLD提供了一个有前途的治疗策略.
- 对线粒体向方法的进一步研究可以显著减少MASLD的全球负担.
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