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Updated: Aug 14, 2026

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针对特定目标的活性发现的高效计算框架:对IL-17C向周期性的案例研究

Zhipeng Wu1, Yejian Wu1, Cheng Zhu1

  • 1Artificial Intelligence Aided Drug Discovery Institute, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Journal of chemical information and modeling
|December 4, 2023
PubMed
概括

本研究介绍了一个使用条件变异自编码器 (CVAE) 和变压器-CNN分类器 (TCPP) 发现活性的计算框架. 在六种合成的中,有四种表现出有前途的结合性亲和力与介素-17C (IL-17C).

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...