在中年妇女健康研究中,酸盐代谢物的年比年变化
Genoa R Warner1, Zhong Li2, Jodi A Flaws3,4
1Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ, USA.
Journal of exposure science & environmental epidemiology
|December 4, 2023
概括
女性的甲酸代谢物水平随着时间的推移而大幅波动. 每年的尿样可能无法准确地捕捉中年妇女长期暴露于甲酸盐的情况.
科学领域:
- 环境健康科学 环境健康科学
- 生殖流行病学 生殖流行病学
- 生物监测 生物监测
背景情况:
- 人类广泛接触甲酸盐是常见的,其代谢物通过尿液迅速分泌.
- 快速排泄导致尿液中甲酸盐生物标志物度的高变化,使暴露评估复杂化.
研究的目的:
- 在中年女性中,鉴定甲酸盐生物标志物度的长期变异性.
- 在中年过渡期间识别与酸盐生物标志物变异性相关的因素.
- 从中年妇女健康研究 (2006-2015年) 获得的纵向尿甲酸代谢物数据的分析.
主要方法:
- 在长达4年的时间里,对741名女性进行了长度研究,每年收集2-4个尿样.
- 九种甲酸盐代谢物的量化,包括代表全甲酸盐 (Phthalates),DEHP (DEHP),塑料 (Plastic),个人护理产品 (PCP) 和抗雄激素作用 (AA) 的总和.
- 统计分析使用一般化的线性模型用于酸盐四分位数和顺序逻辑回归解释变量 (种族,收入,工作类型).
主要成果:
- 随着时间的推移,甲酸盐生物标志物度在中年妇女中表现出相当大的变化.
- 每年采样频率可能不足以进行全面的长期甲酸盐暴露评估.
- 种族,收入和工作类型等因素可能会影响甲酸盐代谢物变异性.
结论:
- 尿液中甲酸盐生物标志物度在中年妇女中具有很大的变化.
- 目前的年度采样策略可能低估了真正的长期甲酸盐暴露.
- 需要进一步的研究来完善在这个人口群体中对甲酸盐的暴露评估方法.
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